What is The Question that drives you?

Neo had his question ("What is the Matrix?"). Hamlet had his question ("To be or not to be...?"). What is the question that drives you? Have you found one, yet? I'm not sure if I have, but it's probably something close to, "How do people learn?" Alan Newell once said that it is the greatest achievement to have found the One Question that you spend the rest of your life seeking an answer. We should all be so lucky.